AskDefine | Define solanine

User Contributed Dictionary



  1. A poisonous glycoalkaloid found in many species of the nightshade family

Extensive Definition

Solanine is a glycoalkaloid poison found in species of the nightshade family, such as potatoes. It can occur naturally in any part of the plant, including the leaves, fruit, and tubers. It is very toxic even in small quantities. Solanine has both fungicidal and pesticidal properties, and it is one of the plant's natural defenses.

Solanine poisoning


Solanine poisoning is primarily displayed by gastrointestinal and neurological disorders. Symptoms include nausea, diarrhea, vomiting, stomach cramps, burning of the throat, heart arrhythmia, headache and dizziness. Hallucinations, loss of sensation, paralysis, fever, jaundice, dilated pupils and hypothermia have been reported in more severe cases.
In large quantities, solanine poisoning can cause death. One study suggests that doses of 2 to 5 mg per kilogram of body weight can cause toxic symptoms, and doses of 3 to 6 mg per kilogram of body weight can be fatal.
Symptoms usually occur 8 to 12 hours after ingestion, but may occur as rapidly as 30 minutes after eating high-solanine foods.

Mechanism of Action

One study suggests that the toxic mechanism of solanine is caused by the chemical's interaction with mitochondrial membranes. Experiments show that solanine exposure opens the potassium channels of mitochondria, increasing their membrane potential. This in turn leads to Ca2+ being transported down its concentration gradient into the mitochondria, and it is this increased concentration of Ca2+ in the cell that triggers cell damage and apoptosis.

Correlation with birth defects

Some studies show a correlation between the consumption of potatoes suffering from late-blight (which increases solanine and other glycoalkaloid levels) and the incidence of congenital spina bifida in humans. However, other studies have shown no correlation between potato consumption and the incidence of birth defects.

Solanine in potatoes

Solanine occurs naturally in all nightshades, including tomatoes, capsicum, tobacco and eggplant, as well as plants from other species. However, most ingested solanine is from the consumption of potatoes.
Potatoes naturally produce solanine and chaconine, a related glycoalkaloid, as a defense mechanism against insects, disease, and predators. Potato leaves and stems and shoots are naturally high in glycoalkaloids.
When potato tubers are exposed to light, they turn green and increase glycoalkaloid production. This is a natural defense to help prevent the uncovered tuber from being eaten. The green colour is from chlorophyll, and is itself harmless. However, it is an indication that increased level of solanine and chaconine may be present.
Some diseases, such as potato blight, can dramatically increase the levels of glycoalkaloids present in potatoes. Mechanically damaged potatoes also produce increased levels of glycoalkaloids. This is believed to be a natural reaction of the plant in response to disease and damage.
Commercial varieties of potatoes are screened for solanine levels, and most have a solanine content of less than 0.2 mg/g. However, potatoes that have been exposed to light and started to green can show concentrations of 1 mg/g or more. In these situations a single unpeeled potato can result in a dangerous dose.
In potato tubers 30–80% of the solanine develops in and close to the skin.
Showing green under the skin strongly suggests solanine build-up in potatoes although each process can occur without the other. A bitter taste in a potato is another, potentially more reliable indicator of toxicity.
The National Institute of Health's information on solanine says to never eat potatoes that are green below the skin.
Deep-frying potatoes at 170°C (306°F) is known to effectively lower glycoalkaloid levels, whereas microwaving is only somewhat effective and boiling has no effect.

Other uses of solanine

Solanine has fungicidal and pesticidal properties, and solanine hydrochloride (a salt of solanine) has been used as a commercial pesticide, but never on a large scale.
Solanine has sedative and anticonvulsant properties, and has been used as a treatment for asthma, as well as for cough and cold medicines. However, its effectiveness for either use is questionable.


External links

solanine in Catalan: Solanina
solanine in Czech: Solanin
solanine in German: Solanin
solanine in Estonian: Solaniin
solanine in Spanish: Solanina
solanine in Esperanto: Solanino
solanine in French: Solanine
solanine in Galician: Solanina
solanine in Icelandic: Sólanín
solanine in Italian: Solanina
solanine in Dutch: Solanine
solanine in Japanese: ソラニン
solanine in Norwegian: Solanin
solanine in Polish: Solanina
solanine in Portuguese: Solanina
solanine in Romanian: Solanină
solanine in Russian: Соланин
solanine in Finnish: Solaniini
solanine in Swedish: Solanin
solanine in Ukrainian: Соланін
Privacy Policy, About Us, Terms and Conditions, Contact Us
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2
Material from Wikipedia, Wiktionary, Dict
Valid HTML 4.01 Strict, Valid CSS Level 2.1